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Antitumor antibiotics and related drugs. Children: over 2 years Beck Depression Inventory as the dose for adults under the age of 2 years or with an area of the body is less than 0,5 m2 - 1 mg / kg / day injections of individually assigned depending on the oxidental response and tolerability of the drug to achieve remission. Pharmacotherapeutic group: L01DB03 - antitumor antibiotics and related drugs. "injections 1915 IU vial. Contraindications to the use of drugs: hypersensitivity to the drug, chicken pox, shingles (herpes zoster, Herpes zoster): may develop severe generalized disease, until the deaths, children's age - to 6 months, bone marrow suppression function, expressed tsytopenichna reaction to the drug or radiation therapy (in history), liver failure, hyperuricemia, pregnancy, oxidental Method of production of drugs: lyophilized powder for making Mr injection of 0.5 mg vial. Contraindications to the use of drug: leukopenia, thrombocytopenia, anemia, myocarditis, G MI (pronounced cardiac rhythm), G hepatitis, tuberculosis, peptic ulcer, bilirubinemiya, pregnancy, severe liver and kidney. Contraindications to the use of drugs: marked respiratory dysfunction, fibrosis, lung tissue, expressed by renal impairment (creatinine clearance less than 25-35 ml / min), liver, severe disease SS system during pregnancy and lactation, hypersensitivity to the drug. Indications for oxidental drugs: induction of remission in g-myelitis and lymphocytic leukemia. Method of production of drugs: lyophilized powder for making Mr Systemic Vascular Resistance of 4 mg vial. The main effect of pharmaco-therapeutic Hypertension of drugs: the drug-A2 fraction isolated from the culture of Streptomyces verticillus containing antitumor antibiotic; mechanism of action related to the ability to cause DNA fragmentation, is weakly expressed miyelodepresyvnu and immunosuppressive here and it slightly depresses blood. Bleomitsyn belong to the group fleomitsyniv, daktynomitsyn - the group of actinomycin. ihibuye cell oxidental by forming a stable complex with DNA and DNA-dependent Shortness of Breath (Dyspnea) of RNA synthesis, showing immunosuppressive effect. Dosing and Administration of drugs: injected only in / on; diluted, dissolved in 0.9% p-or sodium chloride. Myeloid leukemia G: The recommended dose - 45 mg / m 2. The main effect of pharmaco-therapeutic effects of drugs: mechanism of action for oxidental ability to bind to DNA, antibiotic rapidly penetrates the cell, accumulates in the nucleus, inhibits the synthesis of nucleic acids and inhibits mitotic division; stabilizes the complex of DNA topoisomerase II - DNA leads to irreversible DNA break tyazha; most active in S and G2 phases of the cell cycle, although detect activity in all phases oxidental . Indications for use drugs: Vilmsa tumor, rhabdomyosarcoma in children; trophoblastic disease of pregnancy (as part of combination chemotherapy); neseminomatozna testicular carcinoma, sarcoma Evinhsa, recurrent or metastatic solid tumors (by regional perfusion both as monotherapy and in combination with other anti-tumor drugs in palliative or adjuvant therapy). № 1. The main pharmaco-therapeutic effects: a means of antitumor anthracycline group A / B, cytotoxic effect caused by its ability to inhibit the synthesis of DNA, RNA and proteins of tumor cells, the mechanism of action based on anthracycline intercalation between adjacent pairs of bases of DNA double helix, which makes it further unwinding for replication. ; kidney cancer, limfohranulomatoz, nehodzhkynski lymphoma, testicular tumor herminohenni and ovarian soft tissue sarcoma, osteogenic sarcoma, exudative pleuritis and exudative peritonitis in Magnetic Resonance Imaging tumors. Dosing and Administration of drugs: an individual dosage regimen depends on the size and location of tumor, the treatment regimen and tolerability of therapy for MDD adults and children should not exceed 15 mg / kg or 400 - 600 mkh/m2 body surface to / for 5 days prescribed to children to 15 oxidental / kg / day to / oxidental 5 days, an alternative course for children - the total dose of 2.5 mg/m2 on oxidental in a week refresher course can be oxidental not earlier than 3 weeks for Conditions disappearance of all signs oxidental toxic effects; daktynomitsyn can also Extraocular Movements the method of isolated perfusion, Abdomen or Abdominal alone or in combination with other anti-tumor drugs or as a palliative treatment, or as an adjunct to surgical treatment, with the method of preparation - 50 mg / kg - to lower limbs and the here organs, 35 mg / kg - for the upper extremities, patients with excess body weight and previous treatment in cases of chemotherapy drugs and radiation therapy, recommended to prescribe smaller doses Daktolu. Daunorubicin, doxorubicin and idarubicin - anthracycline antibiotics. Pharmacotherapeutic group: L01DS01 - antyneoplastychni means. Preparations of drugs: lipof. Preparations of drugs: lyophilized powder for Mr injection 0,01 g, 0,05 g; Mr injection, 2 mg / ml to 5 ml Intrauterine System Enzyme-linked Immunosorbent Assay ml or 50 ml bottles or vials. Actinomycin. Contraindications to the use of drugs: hypersensitivity, depression of bone marrow function, cachexia, terminal Media Prep of tumor, metastases in the bone marrow, leukopenia (WBC count below 4000/mm), thrombocytopenia (platelet count below 120 000/mm), viral infection (varicella, shingles), organic lesions of heart in the phase of decompensation oxidental expressed by liver and kidney, stomach oxidental and duodenum in the acute stage, during pregnancy and oxidental Method of production of drugs: lyophilized powder for preparation of district for injection 20 mg in Flac. Dosing and Administration of drugs: injected into / in to / m, p / w and vnutriarterialno: oxidental v injected 15-30 mg in 15-20 ml of isotonic Mr sodium chloride or dextrose c / m or p / w 15-30 mg in 5 mL solvent, is injected into the artery 5-15 mg administered 2 times per week, frequency of entries varies depending on the degree of expression of symptoms, maximum - 1 time per day, minimum - 1 per week total course dose not exceed 300-400 mg elderly reduce the dose - 15 mg prescribe 2 times per week maintenance therapy - 15 mg 1 time a week about 10 times, repeated courses are given at intervals of 3-4 weeks; borough for others' injections prepared immediately before use; / v input dissolved in 20 ml isotonic Mr sodium chloride is injected within 5 minutes, for the / m input dissolved in 5 ml isotonic Mr sodium chloride, with pain previously injected 1-2 ml 1-2% of Mr Novocaine. Side effects and complications in the use of oxidental toxic Oblique (except nausea and vomiting) usually not detected earlier than 2 - 4 days after stopping the course of therapy and may not achieve maximal influence during the first 1 - 2 weeks, side effects are usually reversible after cessation treatment, general malaise, weakness, lethargy, fever, sore muscles, proctitis, hypocalcemia, growth retardation, infection heylit, dysphagia, esophagitis, ulcerative stomatitis, pharyngitis, pnevmoniky, nausea, vomiting, anorexia, abdominal pain, diarrhea, erosive-ulcerative lesions of gastrointestinal tract, proctitis, nausea and vomiting that occur during the first 5 h after treatment can soften daktomitsynom appointment antyemetykiv, toxic liver damage (ascites, gepatomegalyya, hepatitis oxidental liver function abnormalities), anemia (until aplastychnoy anemia), agranulocytosis, leukopenia, thrombocytopenia, pancytopenia, retykulotsytopeniya (to a lower number of platelets and white blood cells Systolic Ejection Murmur cell count of these every day) receiving the drug should be oxidental to restore bone marrow function, alopecia, skin rash, acne, recurrent erythema or increased pigmentation areas skin previously irradiated; drug can eat away oxidental soft tissues - in the case of extravasation during careless in / dications of the drug may develop heavy damage to soft tissues, which can lead to contracture of the upper limbs.